D&PS

Daily Issue (Sep 15. 2017)

Regenerative Surgery
#20-2. Hair Follicle Stem Cells

Follicle cells at the follicle base continue mitosis, congregate to form a column. Cells directly above the actively dividing cells die from dehydration and become keratin. Keratin filaments adhere together through cysteine rich matrix and form a hair shaft. The dermal papilla that lies below the mitotic cells at the follicle base plays an important role in regulating hair growth. Hair growth is not continuous but cyclical. That is, hair goes through stages of repeated active growth and rest. During anagen phase, hair goes through active growth. About 90% of allterminal hair is in anagen phase which lasts about 3 years. In the catagen phase, follicle base keratinize, shrinks and detaches from the papilla. Melanocytes no longer produce melanin. The catagen phase continues for 1-2 weeks. In the telogen phase, follicle loses activity, rests and there is no hair growth. Hair shaft…

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