• #1-2. Introduction to Intravenous Nutrition Therapy

     

    Cautions for concocting the IV solution

    One does not have to be cautious about too many things when administering the nutrition therapy. However, close attention must be given to the following.

    First, the doctor should clearly understand the ingredients that must NOT be combined.

    ① Calcium and sodium hydrogen carbonate should not be combined in the same solution. It creates calcium carbonate precipitates.

    ② Vitamin C and selenium cannot be mixed. Selenium precipitates are formed.

    Second, an appropriate base solution should be selected.

    ① Avoid using glucose in patients with diabetes or cancer.

    ② Use distilled water for injection with higher concentration of Vitamin C(30g or higher). This is due to the Na-ascorbic acid form of vitamin C and osmotic pressure.

    ③ Products containing amino acid should not be mixed in the amino acid solution. For example, licorice and glutathione should be mixed in saline solution. Combining these ingredients with amino acid solution can remove their efficacy.

    ④ I recommend mixing minerals in amino acid solution. Combination of amino acid and minerals promote absorption and prevent deposits.

    Third, ingredients that are prone to oxidation should be combined in a small dose solution and immediately administered. This type of ingredients include glutathione, and lipoic acid. They should be combined in 50-100ml of saline solution and infused 2-3 drips per second. The drip infusion should take no longer than 10 minutes.

     

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    Vitamin C mega dose therapy

    Vitamin C has a wide variety of indications. First, for anti-oxidation, vitamin C can be used in fatigue, anti-aging, anti-virus, and liver function improvement. Second, as collagen component, vitamin C strengthens various connective tissues. Third, vitamin C chelation of vascular wall calcium can help prevent vascular diseases such as atherosclerosis as well as improve circulation. Vitamin C can promote healing in dermatologic conditions and wound care. The most promising new use of vitamin C is cancer management. Vitamin C brings different degrees of efficacy depending on the mode of administration. Unlike ingestion, high-dose vitamin C injection allows complete absorption of all active ingredients into the blood stream and can increase the expected efficacy. However, oral vitamin C tablets have an inconsistent rate of absorption depending on the person or physical conditions at the time of intake. Oral vitamin C has low absorption and is expected to bring mild antioxidative effects. Unabsorbed vitamin C is excreted and can cause diarrhea. I use high-dose vitamin C in patients with constipation to induce diarrhea. The patient satisfaction is very high with this method. Injectable vitamin C is fully absorbed into blood vessels and have differing effects depending on the dose. Generally, injection of 5-30g vitamin C is expected to bring antioxidative effects(anti-aging, fatigue relief, stronger health). On the other hand, injection of 50g-100g intends to go over the anti-oxidative effect and utilizes oxidized vitamin C one more time. The chemical structure of vitamin C is very similar to glucose. It is allowed into the cell through the GLUT(glucose transporter) along with glucose to induce oxidative damage to cancer cells with H2O2.VitaminCcanbeusedintargettherapyincancer.

    Vitamin C can be combined in saline or glucose solutions. Angiodynia occurring during injection is most likely be caused by the osmolarity of the solution being infused. Therefore, the vitamin C dose should not exceed 10g(20ml) for each 100ml of saline or glucose solution. Doses lower than this are relatively safe. In other words, 20g of vitamin C should be mixed in at least 200ml base solution. Over 500ml of saline solution would be safe but not 100ml. Use distilled water when using vitamin C dose of 30g or higher. Injectable vitamin C is in the form of Na-ascorbic acid and 30-40g of Na-ascorbic acid combined in 500ml of saline solution drastically increases the amount of Na+, potentially leading to vascular stiffness or other Na+-related side effects. A small amount of Beecom or magnesium can be mixed in the solution. A safe dose of vitamin C for the very first IVNT treatment would be 10-20g for optimal safety and efficacy. Raise the dose to 30g only after the patient is used to greater exposure.

     

    Myer’s cocktail therapy

    The high-dose vitamin C IV therapy can be most easily upgraded to Myers' cocktail. Myer’s cocktail adds vitamins B5, B6, and B12 as well as an increased dose of magnesium to the base of high-dose vitamin C solution. Vitamins B5, B6, and B12 are often nicknamed the three musketeers of Myer. One should pay attention to vitamins B5, B6, and B12 and magnesium because the three vitamins of the Vitamin B group are deeply involved in energy metabolism and particularly, vitamin B6 enhances the efficacy of magnesium. This concoction can effectively help the most common symptoms in patients with chronic fatigue such as lowered basal metabolism, various nonspecific pains and anxiety, etc. Myer’s cocktail can provide sedative comfort, promote energy metabolism and reduce pain more effectively than high-dose vitamin C therapy.

     

    Licorice IV therapy

    Licorice is a perennial legume plant originating from northeastern China, Siberia and Mongolia, etc. It is harvested around the world and used in food and medicine, etc. Its binomial name is glycyrrhiza uralensis. The sweet flavor of licorice root is 50 times more powerful than sugar and is widely used in medicine and sweetener. Licorice-derived ingredients are added in the licorice IV solution. One ampoule(20ml) contains 40mg of glycyrrhizin, 400mg of glycine, and 20mg of L-cysteine hydrochliride. The most widely known ingredient among these is glycyrrhizin and licorice once was falsely regarded as a steroid. Cortisol secreted from the adrenal cortex is converted into cortisone in the kidney. Glycyrrhizin inhibits the hormones involved in this process to lengthen the duration of cortisol action. Therefore, it aids the action of cortisol, a key stress hormone, to maintain its positive action. The key effect of licorice IV therapy is the positive action of steroid without its negative effects. In short, its effects may include anti-inflammatory and anti-allergic actions, liver function improvement, immune support, anti-viral action, and improved digestion, etc. It has the added benefit of reducing side effects when combined with other injections and can be used in all IVNT treatments. A butterfly needle can be safely used for direct intravenous injection, or licorice can be added to other solutions. However, I try to avoid combining licorice ingredients with amino acid solution due to negative interactions with glycine and cysteine.

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