#11-2. Biological Dressing Ⅱ

▶ Previous Artlcle : #11-1. Biological Dressing Ⅱ

Much like a regular wound dressing, Kaloderm proviedes a barrier that blocks water loss to prevent dehydration and protects the wound from infection and physical stimuli. It also provides adequate amount of protein necessary in all phases of the wound healing process.

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The process of wound healing progresses from 1) inflammatory phase 2) proliferative phase to 3) maturation and remodeling phase where cells and tissues are reorganized. It promotes proliferation and migration of undamaged skin stem cells in the tissues and skin appendages surrounding the wound by releasing large amounts of cytokines and extracellular matrix, etc. It also stimulates fibroblasts to accelerate generation of extracellular matrix such as collagen. It also inhibits formation of hypertrophic scar by controlling hypersynthesis of collagen by releasing collagenases including MMP-1, MMP-2, and MMP-9.

Kaloderm is also effective in treatment of diabetic foot ulcer, adding an indication for the condition in 2010. Starting 2011, it has been marketed in various sizes (9cm2·16cm2·25cm2·56cm2). Currently, Kaloderm is universally used not only in burn treatment but in treatment of diabetic foot ulcer, and abrasion in burn care centers and general hospitals of Korea. Therefore, skin cell therapy, especially CEH is expected to grow faster in the near future as it does not require culture period of over two weeks and can be used immediately in burn, foot ulcer treatment, cornea regeneration, promotion of skin regeneration after laser treatment, aesthetic procedures as well as gene therapy.