• #7-3. Multiple Therapeutics for Hair Loss Ⅰ



    ▶ Previous Artlcle #7-2. Multiple Therapeutics for Hair Loss Ⅰ 



    Nocebo Effect


    The nocebo effect is defined as a phenomenon where a patient's negative expectations as to treatment, such as believing that the intervention will cause harm or will be ineffective, could negatively impact the patient's recovery.


    For example, when a patient believes that taking a hair loss medication may induce decreased virility, a negative outcome could occur.



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    However, therapeutic agents for hair loss inhibit DHT. A hormone associated with virility including erectility is not DHT but testosterone, a male hormone, and therefore virility is unrelated to hair loss medications.


    According to a clinical case, in reality, patients were divided into two groups depending on whether to be informed of potential sexual function-related adverse effects as their medications were prescribed, and subsequently these two patient groups were followed up for one year.


    As a result, the incidence of adverse events (impotence, decreased libido, and ejaculation disorder) was found to increase significantly (approximately 3-fold) in the informed patient group.


    It can be said that a saying "ignorance is bliss" fits this situation very well.


    There have been reports that adverse events associated with hair loss medications had an incidence of approximately 2 to 3% and were mostly reversible after treatment withdrawal, and that even after continuation of the treatment, 57% experienced improvements in relevant symptoms.



    Figure 2. Frequently prescribed drugs in dutasteride class.




    -To be continued

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